Professor Magdi Yaqoob

Professor Yaqoob leads the Nephrology and Transplant Medicine Research Group

We have a long-standing research interest in the pathophysiology and novel therapeutic strategies (preclinical and clinical) of:

1. Ischaemia-reperfusion of the heart in uraemia and kidney (acute kidney injury, chronic kidney disease, renal fibrosis)

2. Genetic factors determining the long-term outcomes of renal transplants

3. Insulin resistance in CKD

4. Autophagy and premature ageing in uraemia

5. Molecular mechanisms of EPO resistance.

Over the years, we have identified a number of new therapeutic targets poly (ADP-ribose) polymerase (PARP), Hypoxiainducible factor stabilizers, calpain/caspases, acidosis, anti-inflammatory suppression of cytokine signalling, pleiotropic effects of erythropoietin their analogues, ischaemic preconditioning, sodium sensing in endothelial cells and galectins 1 & 3 in microcirculatory unit to name but a few. More recently as part of the NIHR-funded Barts-BRU, we have focused on the development of highly translational repositioning strategies, the efficacy of which is currently evaluated in patients with chronic kidney disease and transplant waiting list patient.

Our current PhD students and their field of research are:

Michelle A: renal transplant, post transplant diabetes melitus, drug trials

David: microbiome and CKD

Caesar: Torque tenovirus and renal transplant

Ritwika: acidosis and CKD

Gregor Y: SGLT2is and podocytes