Professor Alan Salama
Renal inflammation & autoimmunity
Our focus is on understanding the balance between factors causing inflammatory kidney disease and the natural regulatory mechanisms that keep them in check. Defining these factors may provide better ideas of how to monitor disease, predict those who need treatment and lead to better therapeutic strategies.
Our main clinical interest is in small vessel vasculitis and systemic lupus erythematosus as the important diseases in which there is dysregulated immunity. Understanding how to better treat these diseases, in which therapy can lead to significant side effects, is critical with new options becoming available. Testing new strategies and protocols as part of clinical trials is an important part of our work
Experimentally, we use animal models of ischaemia reperfusion and glomerulonephritis, while we have in vitro models using cell cultures and granuloma formation to investigate the basis of the immune dysregulation.
